1BWB

HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH SD146 OF DUPONT PHARMACEUTICALS

1BWB の概要

• エントリーDOI: 10.2210/pdb1bwb/pdb
• 分子名称: PROTEIN (HIV-1 PROTEASE), [4R-(4ALPHA,5ALPHA,6ALPHA,7ALPHA)]-3,3'-{{TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-DIYL]BIS(METHYLENE)]BIS[N-1H-BENZIMIDAZOL-2-YLBENZAMIDE] (3 entities in total)
• 機能のキーワード: hiv-1 protease, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22472.42

構造登録者

Ala, P.,Chang, C.H. (登録日: 1998-09-22, 公開日: 1998-09-30, 最終更新日: 2024-02-07)

• 主引用文献: Ala, P.J.,Huston, E.E.,Klabe, R.M.,Jadhav, P.K.,Lam, P.Y.,Chang, C.H.; Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.; Biochemistry, 37:15042-15049, 1998; PubMed: 9790666; DOI: 10.1021/bi980386e

実験手法

X-RAY DIFFRACTION (1.8 Å)