1BU2

X-RAY STRUCTURE OF A VIRAL CYCLIN FROM HERPESVIRUS SAIMIRI

1BU2 の概要

• エントリーDOI: 10.2210/pdb1bu2/pdb
• 分子名称: CYCLIN HOMOLOG (1 entity in total)
• 機能のキーワード: cell cycle regulation, herpesvirus saimiri, viral cyclin
• 由来する生物種: Herpesvirus saimiri (strain 11)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25849.15

構造登録者

Schulze-Gahmen, U.,Jung, J.U.,Kim, S.-H. (登録日: 1998-09-10, 公開日: 1999-06-15, 最終更新日: 2024-02-07)

主引用文献

Schulze-Gahmen, U.,Jung, J.U.,Kim, S.H.
Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6.
Structure Fold.Des., 7:245-254, 1999

PubMed Abstract: Cyclin-dependent kinases (CDKs) have a central role in cell-cycle control and are activated by complex formation with positive regulatory proteins called cyclins and by phosphorylation. The overexpression and mutation of cyclins and CDKs has been associated with tumorigenesis and oncogenesis. A virus-encoded cyclin (v-cyclin) from herpesvirus saimiri has been shown to exhibit highest sequence homology to type D cyclins and specifically activates CDK6 of host cells to a very high degree.

PubMed: 10368294
DOI: 10.1016/S0969-2126(99)80035-5

実験手法

X-RAY DIFFRACTION (3 Å)