1BQ1
E. COLI THYMIDYLATE SYNTHASE MUTANT N177A IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)
Summary for 1BQ1
| Entry DOI | 10.2210/pdb1bq1/pdb |
| Descriptor | THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total) |
| Functional Keywords | transferase, active site mutant, reaction intermediate |
| Biological source | Escherichia coli |
| Cellular location | Cytoplasm : P0A884 |
| Total number of polymer chains | 2 |
| Total formula weight | 62604.59 |
| Authors | Reyes, C.L.,Sage, C.R.,Rutenber, E.E.,Finer-Moore, J.S.,Stroud, R.M. (deposition date: 1998-08-20, release date: 1999-05-18, Last modification date: 2021-11-03) |
| Primary citation | Reyes, C.L.,Sage, C.R.,Rutenber, E.E.,Nissen, R.M.,Finer-Moore, J.S.,Stroud, R.M. Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer. J.Mol.Biol., 284:699-712, 1998 Cited by PubMed: 9826509DOI: 10.1006/jmbi.1998.2205 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report
