1BPV

TITIN MODULE A71 FROM HUMAN CARDIAC MUSCLE, NMR, 50 STRUCTURES

Summary for 1BPV

Entry DOI	10.2210/pdb1bpv/pdb
Descriptor	TITIN (1 entity in total)
Functional Keywords	titin, connectin, fibronectin type iii
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	12476.98
Authors	Muhle-Goll, C.,Pastore, A.,Nilges, M. (deposition date: 1998-08-11, release date: 1999-08-12, Last modification date: 2024-05-22)
Primary citation	Goll, C.M.,Pastore, A.,Nilges, M. The three-dimensional structure of a type I module from titin: a prototype of intracellular fibronectin type III domains. Structure, 6:1291-1302, 1998 Cited by PubMed Abstract: Titin is a huge protein ( approximately 3 MDa) that is present in the contractile unit (sarcomere) of striated muscle and has a key role in muscle assembly and elasticity. Titin is mainly composed of two types of module (type I and II). Type I modules are found exclusively in the region of titin localised in the A band, where they are arranged in a super-repeat pattern that correlates with the ultrastructure of the thick filament. No structure of a titin type I module has been reported so far. PubMed: 9782056 DOI: 10.1016/S0969-2126(98)00129-4 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation