1BOB

HISTONE ACETYLTRANSFERASE HAT1 FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH ACETYL COENZYME A

1BOB の概要

• エントリーDOI: 10.2210/pdb1bob/pdb
• 分子名称: HISTONE ACETYLTRANSFERASE, CALCIUM ION, ACETYL COENZYME *A, ... (4 entities in total)
• 機能のキーワード: histone acetyltransferase, histone modification, acetyl coenzyme a binding-protein, acetyltransferase
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38415.99

構造登録者

Dutnall, R.N.,Tafrov, S.T.,Sternglanz, R.,Ramakrishnan, V. (登録日: 1998-07-02, 公開日: 1999-04-20, 最終更新日: 2024-02-07)

主引用文献

Dutnall, R.N.,Tafrov, S.T.,Sternglanz, R.,Ramakrishnan, V.
Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily.
Cell(Cambridge,Mass.), 94:427-438, 1998

PubMed Abstract: We have solved the crystal structure of the yeast histone acetyltransferase Hat1-acetyl coenzyme A (AcCoA) complex at 2.3 A resolution. Hat1 has an elongated, curved structure, and the AcCoA molecule is bound in a cleft on the concave surface of the protein, marking the active site of the enzyme. A channel of variable width and depth that runs across the protein is probably the binding site for the histone substrate. A model for histone H4 binding by Hat1 is discussed in terms of possible sources of specific lysine recognition by the enzyme. The structure of Hat1 provides a model for the structures of the catalytic domains of a protein superfamily that includes other histone acetyltransferases such as Gcn5 and CBP.

PubMed: 9727486
DOI: 10.1016/S0092-8674(00)81584-6

実験手法

X-RAY DIFFRACTION (2.3 Å)