1BMQ

CRYSTAL STRUCTURE OF THE COMPLEX OF INTERLEUKIN-1BETA CONVERTING ENZYME (ICE) WITH A PEPTIDE BASED INHIBITOR, (3S )-N-METHANESULFONYL-3-({1-[N-(2-NAPHTOYL)-L-VALYL]-L-PROLYL }AMINO)-4-OXOBUTANAMIDE

1BMQ の概要

• エントリーDOI: 10.2210/pdb1bmq/pdb
• 分子名称: PROTEIN (INTERLEUKIN-1 BETA CONVERTASE), (3S)-N-METHANESULFONYL-3-({1-[N-(2-NAPHTOYL)-L-VALYL]-L-PROLYL}AMINO)-4-OXOBUTANAMIDE (3 entities in total)
• 機能のキーワード: caspase, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: P29466 P29466
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29614.10

構造登録者

Okamoto, Y.,Anan, H.,Nakai, E.,Morihira, K.,Yonetoku, Y.,Kurihara, H.,Katayama, N.,Sakashita, H.,Terai, Y.,Takeuchi, M.,Shibanuma, T.,Isomura, Y. (登録日: 1998-07-24, 公開日: 1998-07-29, 最終更新日: 2023-08-09)

• 主引用文献: Okamoto, Y.,Anan, H.,Nakai, E.,Morihira, K.,Yonetoku, Y.,Kurihara, H.,Sakashita, H.,Terai, Y.,Takeuchi, M.,Shibanuma, T.,Isomura, Y.; Peptide based interleukin-1 beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex.; Chem.Pharm.Bull., 47:11-21, 1999; PubMed: 9987822

実験手法

X-RAY DIFFRACTION (2.5 Å)