1BMA

BENZYL METHYL AMINIMIDE INHIBITOR COMPLEXED TO PORCINE PANCREATIC ELASTASE

1BMA の概要

• エントリーDOI: 10.2210/pdb1bma/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000358
• 分子名称: Chymotrypsin-like elastase family member 1, CALCIUM ION, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: serine protease, metal-binding, protease, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Sus scrofa (pigs,swine,wild boar)
• 細胞内の位置: Secreted: P00772
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26585.77

構造登録者

Peisach, E.,Casebier, D.,Gallion, S.L.,Furth, P.,Petsko, G.A.,Hogan Jr., J.C.,Ringe, D. (登録日: 1995-05-01, 公開日: 1995-12-07, 最終更新日: 2024-10-23)

主引用文献

Peisach, E.,Casebier, D.,Gallion, S.L.,Furth, P.,Petsko, G.A.,Hogan Jr., J.C.,Ringe, D.
Interaction of a peptidomimetic aminimide inhibitor with elastase.
Science, 269:66-69, 1995

PubMed Abstract: The crystal structure of an aminimide analog of a dipeptide inhibitor of porcine pancreatic elastase bound to its target serine protease has been solved. The peptidomimetic molecule binds in the same fashion as the class of dipeptides from which it was derived, making similar interactions with the subsites on the elastase surface. Because aminimides are readily synthesized from a wide variety of starting materials, they form the basis for a combinatorial chemistry approach to rational drug design.

PubMed: 7604279

実験手法

X-RAY DIFFRACTION (1.8 Å)