1BJI

THE X-RAY STRUCTURE OF A COMPLEX OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE COMPLEXED WITH THE GLAXO 6-CARBOXAMIDE SIALIC ACID ANALOGUE GR217029

Summary for 1BJI

• Entry DOI: 10.2210/pdb1bji/pdb
• Descriptor: NEURAMINIDASE, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose, ... (7 entities in total)
• Functional Keywords: neuraminidase, influenza protein, inhibitor complex, 6-carboxamide derivative, sialic acid analogue, glaxo gr217029, hydrolase, glycoprotein
• Biological source: Influenza A virus
• Cellular location: Virion membrane (By similarity): P03472
• Total number of polymer chains: 1
• Total formula weight: 45848.83

Authors

Varghese, J.N. (deposition date: 1997-12-03, release date: 1998-06-03, Last modification date: 2024-04-03)

• Primary citation: Taylor, N.R.,Cleasby, A.,Singh, O.,Skarzynski, T.,Wonacott, A.J.,Smith, P.W.,Sollis, S.L.,Howes, P.D.,Cherry, P.C.,Bethell, R.,Colman, P.,Varghese, J.; Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.; J.Med.Chem., 41:798-807, 1998; PubMed: 9526556; DOI: 10.1021/jm9703754

Experimental method

X-RAY DIFFRACTION (2 Å)