1BJ4

RECOMBINANT SERINE HYDROXYMETHYLTRANSFERASE (HUMAN)

1BJ4 の概要

• エントリーDOI: 10.2210/pdb1bj4/pdb
• 分子名称: Serine hydroxymethyltransferase, cytosolic, PYRIDOXAL-5'-PHOSPHATE (3 entities in total)
• 機能のキーワード: transferase, metabolic role, pyridoxal 5'-phosphate
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P34896
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51971.00

構造登録者

Renwick, S.B.,Snell, K. (登録日: 1998-07-02, 公開日: 1999-08-16, 最終更新日: 2023-02-08)

主引用文献

Renwick, S.B.,Snell, K.,Baumann, U.
The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy
Structure, 6:1105-1116, 1998

PubMed Abstract: Serine hydroxymethyltransferase (SHMT) is a ubiquitous enzyme found in all prokaryotes and eukaryotes. As an enzyme of the thymidylate synthase metabolic cycle, SHMT catalyses the retro-aldol cleavage of serine to glycine, with the resulting hydroxymethyl group being transferred to tetrahydrofolate to form 5, 10-methylene-tetrahydrofolate. The latter is the major source of one-carbon units in metabolism. Elevated SHMT activity has been shown to be coupled to the increased demand for DNA synthesis in rapidly proliferating cells, particularly tumour cells. Consequently, the central role of SHMT in nucleotide biosynthesis makes it an attractive target for cancer chemotherapy.

PubMed: 9753690
DOI: 10.1016/S0969-2126(98)00112-9

実験手法

X-RAY DIFFRACTION (2.65 Å)