1BIW
DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS
Summary for 1BIW
Entry DOI | 10.2210/pdb1biw/pdb |
Descriptor | PROTEIN (STROMELYSIN-1 COMPLEX), ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | stromelysin, matrix metalloprotease, osteoarthritis, structure-based drug design, protein crystal structure, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix (Probable): P08254 |
Total number of polymer chains | 2 |
Total formula weight | 39750.69 |
Authors | Natchus, M.G.,Cheng, M.,Wahl, C.T.,Pikul, S.,Almstead, N.G.,Bradley, R.S.,Taiwo, Y.O.,Mieling, G.E.,Dunaway, C.M.,Snider, C.E.,McIver, J.M.,Barnett, B.L.,McPhail, S.J.,Anastasio, M.B.,De, B. (deposition date: 1998-06-19, release date: 1999-07-16, Last modification date: 2023-12-27) |
Primary citation | Natchus, M.G.,Cheng, M.,Wahl, C.T.,Pikul, S.,Almstead, N.G.,Bradley, R.S.,Taiwo, Y.O.,Mieling, G.E.,Dunaway, C.M.,Snider, C.E.,McIver, J.M.,Barnett, B.L.,McPhail, S.J.,Anastasio, M.B.,De, B. Design and synthesis of conformationally-constrained MMP inhibitors. Bioorg.Med.Chem.Lett., 8:2077-2080, 1998 Cited by PubMed: 9873489DOI: 10.1016/S0960-894X(98)00370-9 PDB entries with the same primary citation |
Experimental method |
Structure validation
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