1BIM
CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS
Summary for 1BIM
Entry DOI | 10.2210/pdb1bim/pdb |
Descriptor | Renin, (2S)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N~1~-{(1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-2-[(3R)-1,5,5-trimethyl-2-oxopyrrolidin-3-yl]ethyl}-N~4~-[2-(dimethylamino)-2-oxoethyl]-N~4~-[(1S)-1-phenylethyl]butanediamide (2 entities in total) |
Functional Keywords | aspartic proteinase, aspartyl protease, cleavage on pair of basic residues, disease mutation, disulfide bond, glycoprotein, hydrolase, membrane, protease, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 75245.02 |
Authors | Tong, L. (deposition date: 1995-09-27, release date: 1996-01-29, Last modification date: 2022-03-09) |
Primary citation | Tong, L.,Pav, S.,Lamarre, D.,Simoneau, B.,Lavallee, P.,Jung, G. Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors. J.Biol.Chem., 270:29520-29524, 1995 Cited by PubMed: 7493993DOI: 10.1074/jbc.270.49.29520 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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