1BII

THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110

Summary for 1BII

• Entry DOI: 10.2210/pdb1bii/pdb
• Descriptor: MHC CLASS I H-2DD, BETA-2 MICROGLOBULIN, DECAMERIC PEPTIDE, ... (4 entities in total)
• Functional Keywords: complex (mhc i-peptide), major histocompatibility complex class i dd, transmembrane, glycoprotein, complex (mhc i-peptide) complex, complex (mhc i/peptide)
• Biological source: Mus musculus (house mouse); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01900; Secreted: P01887
• Total number of polymer chains: 3
• Total formula weight: 56078.59

Authors

Achour, A.,Persson, K.,Harris, R.A.,Sundback, J.,Sentman, C.L.,Lindqvist, Y.,Schneider, G.,Karre, K. (deposition date: 1998-06-11, release date: 1998-10-14, Last modification date: 2024-11-20)

Primary citation

Achour, A.,Persson, K.,Harris, R.A.,Sundback, J.,Sentman, C.L.,Lindqvist, Y.,Schneider, G.,Karre, K.
The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition.
Immunity, 9:199-208, 1998

PubMed Abstract: The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includes a deep narrow passage accomodating the N-terminal part of the peptide, explaining the obligatory G2P3 anchor motif. Toward the C-terminal half of the peptide, p5R to p8V form a type I' reverse turn; residues p6A to p9T, and in particular p7F, are readily exposed. The structure is discussed in relation to functional data available for T cell and natural killer cell recognition of the H-2Dd molecule.

PubMed: 9729040
DOI: 10.1016/S1074-7613(00)80602-0

Experimental method

X-RAY DIFFRACTION (2.4 Å)