1BG3

RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE

Summary for 1BG3

• Entry DOI: 10.2210/pdb1bg3/pdb
• Descriptor: HEXOKINASE, beta-D-glucopyranose, 6-O-phosphono-alpha-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: hexokinase, phosphotransferase
• Biological source: Rattus norvegicus (Norway rat)
• Total number of polymer chains: 2
• Total formula weight: 206891.56

Authors

Mulichak, A.M.,Garavito, R.M. (deposition date: 1998-06-04, release date: 1999-06-08, Last modification date: 2024-04-03)

Primary citation

Mulichak, A.M.,Wilson, J.E.,Padmanabhan, K.,Garavito, R.M.
The structure of mammalian hexokinase-1.
Nat.Struct.Biol., 5:555-560, 1998

PubMed Abstract: We have determined the structures of the glucose-6-phosphate (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the G6P-sensitive 50,000 Mr hexokinase from Schistosoma mansoni at a resolution of 2.8 and 2.6 A respectively. The structures define the glucose and G6P binding sites in these enzymes, suggest the mechanisms of intradomain G6P inhibition and activity loss in the Type I hexokinase N-terminal half, and reveal the structure of the membrane targeting motif that integrates the Type I hexokinase into the outer mitochondrial membrane.

PubMed: 9665168
DOI: 10.1038/811

Experimental method

X-RAY DIFFRACTION (2.8 Å)