1BDY

C2 DOMAIN FROM PROTEIN KINASE C DELTA

1BDY の概要

• エントリーDOI: 10.2210/pdb1bdy/pdb
• 分子名称: PROTEIN KINASE C (2 entities in total)
• 機能のキーワード: protein kinase c, c2 domain, calcium, calcium-binding, duplication, atp-binding, transferase
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Cytoplasm: P09215
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28028.42

構造登録者

Pappa, H.,Murray-Rust, J.,Dekker, L.V.,Parker, P.J.,Mcdonald, N.Q. (登録日: 1998-05-11, 公開日: 1998-10-14, 最終更新日: 2024-02-07)

主引用文献

Pappa, H.,Murray-Rust, J.,Dekker, L.V.,Parker, P.J.,McDonald, N.Q.
Crystal structure of the C2 domain from protein kinase C-delta.
Structure, 6:885-894, 1998

PubMed Abstract: The protein kinase C (PKC) family of lipid-dependent serine/theonine kinases plays a central role in many intracellular eukaryotic signalling events. Members of the novel (delta, epsilon, eta, theta) subclass of PKC isotypes lack the Ca2+ dependence of the conventional PKC isotypes and have an N-terminal C2 domain, originally defined as V0 (variable domain zero). Biochemical data suggest that this domain serves to translocate novel PKC family members to the plasma membrane and may influence binding of PKC activators.

PubMed: 9687370
DOI: 10.1016/S0969-2126(98)00090-2

実験手法

X-RAY DIFFRACTION (2.2 Å)