1BDG

HEXOKINASE FROM SCHISTOSOMA MANSONI COMPLEXED WITH GLUCOSE

1BDG の概要

• エントリーDOI: 10.2210/pdb1bdg/pdb
• 分子名称: HEXOKINASE, alpha-D-glucopyranose, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hexokinase, phosphotransferase
• 由来する生物種: Schistosoma mansoni
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50979.27

構造登録者

Mulichak, A.M.,Garavito, R.M. (登録日: 1998-05-08, 公開日: 1999-05-11, 最終更新日: 2024-10-16)

主引用文献

Mulichak, A.M.,Wilson, J.E.,Padmanabhan, K.,Garavito, R.M.
The structure of mammalian hexokinase-1.
Nat.Struct.Biol., 5:555-560, 1998

PubMed Abstract: We have determined the structures of the glucose-6-phosphate (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the G6P-sensitive 50,000 Mr hexokinase from Schistosoma mansoni at a resolution of 2.8 and 2.6 A respectively. The structures define the glucose and G6P binding sites in these enzymes, suggest the mechanisms of intradomain G6P inhibition and activity loss in the Type I hexokinase N-terminal half, and reveal the structure of the membrane targeting motif that integrates the Type I hexokinase into the outer mitochondrial membrane.

PubMed: 9665168
DOI: 10.1038/811

実験手法

X-RAY DIFFRACTION (2.6 Å)