1BDA

CATALYTIC DOMAIN OF HUMAN SINGLE CHAIN TISSUE PLASMINOGEN ACTIVATOR IN COMPLEX WITH DANSYL-EGR-CMK (DANSYL-GLU-GLY-ARG CHLOROMETHYL KETONE)

Summary for 1BDA

Related PRD IDPRD_000413
DescriptorSINGLE CHAIN TISSUE TYPE PLASMINOGEN ACTIVATOR, N-{[5-(dimethylamino)naphthalen-2-yl]sulfonyl}-L-alpha-glutamyl-N-[(1S)-4-{[amino(iminio)methyl]amino}-1-(chloroacetyl)butyl]glycinamide (3 entities in total)
Functional Keywordstrypsin like serine protease, fibrinolytic enzymes, plasminogen activators, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space P00750
Total number of polymer chains2
Total molecular weight60705.57
Authors
Bode, W.,Renatus, M.,Engh, R.A. (deposition date: 1998-05-07, release date: 1999-05-11, Last modification date: 2012-12-12)
Primary citation
Renatus, M.,Engh, R.A.,Stubbs, M.T.,Huber, R.,Fischer, S.,Kohnert, U.,Bode, W.
Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.
EMBO J., 16:4797-4805, 1997
PubMed: 9305622 (PDB entries with the same primary citation)
DOI: 10.1093/emboj/16.16.4797
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.35 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers282.7%8.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1bda.pdb1.gz [45.68 KB])
Coordinate files for Biological unit (1bda.pdb2.gz [46.12 KB])