1BDA
CATALYTIC DOMAIN OF HUMAN SINGLE CHAIN TISSUE PLASMINOGEN ACTIVATOR IN COMPLEX WITH DANSYL-EGR-CMK (DANSYL-GLU-GLY-ARG CHLOROMETHYL KETONE)
Summary for 1BDA
Entry DOI | 10.2210/pdb1bda/pdb |
Related PRD ID | PRD_000413 |
Descriptor | SINGLE CHAIN TISSUE TYPE PLASMINOGEN ACTIVATOR, N-{[5-(dimethylamino)naphthalen-2-yl]sulfonyl}-L-alpha-glutamyl-N-[(1S)-4-{[amino(iminio)methyl]amino}-1-(chloroacetyl) butyl]glycinamide (3 entities in total) |
Functional Keywords | trypsin like serine protease, fibrinolytic enzymes, plasminogen activators, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space: P00750 |
Total number of polymer chains | 2 |
Total formula weight | 60705.57 |
Authors | Bode, W.,Renatus, M.,Engh, R.A. (deposition date: 1998-05-07, release date: 1999-05-11, Last modification date: 2023-08-02) |
Primary citation | Renatus, M.,Engh, R.A.,Stubbs, M.T.,Huber, R.,Fischer, S.,Kohnert, U.,Bode, W. Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA. EMBO J., 16:4797-4805, 1997 Cited by PubMed: 9305622DOI: 10.1093/emboj/16.16.4797 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.35 Å) |
Structure validation
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