1B5G

HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN

1B5G の概要

• エントリーDOI: 10.2210/pdb1b5g/pdb
• 分子名称: ALPHA-THROMBIN, HIRUGEN, [[[(4S,5S)-4-[[(3S,6S,8aR)-6-azanyl-5-oxo-6-(phenylmethyl)-1,2,3,7,8,8a-hexahydroindolizin-3-yl]carbonylamino]-5-(1,3-b enzothiazol-2-yl)-5-hydroxy-pentyl]amino]-azanyl-methylidene]azanium, ... (6 entities in total)
• 機能のキーワード: serine protease-inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P09945; Secreted: P00734
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 36022.01

構造登録者

St Charles, R.,Tulinsky, A.,Kahn, M. (登録日: 1998-03-05, 公開日: 1998-05-27, 最終更新日: 2024-06-05)

• 主引用文献: St Charles, R.,Matthews, J.H.,Zhang, E.,Tulinsky, A.; Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.; J.Med.Chem., 42:1376-1383, 1999; PubMed: 10212123; DOI: 10.1021/jm980052n

実験手法

X-RAY DIFFRACTION (2.07 Å)