1AWH

NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT

Summary for 1AWH

• Entry DOI: 10.2210/pdb1awh/pdb
• Descriptor: ALPHA THROMBIN, 3-ACETOXY-17-(1-FORMYL-5-METHYL-3-OXO-HEX-4-ENYL)-16-HYDROXY-4,10,13,14-TETRAMETHYL-2,3,4,5,6,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE-4-CARBOXYLIC ACID, ... (4 entities in total)
• Functional Keywords: proteinase, blood coagulation, trypsin like proteinase, complex (protease-inhibitor), complex (protease-inhibitor) complex, complex (protease/inhibitor)
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 4
• Total formula weight: 68838.91

Authors

Jhoti, H.,Cleasby, A.,Wonacott, A. (deposition date: 1997-10-02, release date: 1998-10-28, Last modification date: 2024-04-03)

• Primary citation: Weir, M.P.,Bethell, S.S.,Cleasby, A.,Campbell, C.J.,Dennis, R.J.,Dix, C.J.,Finch, H.,Jhoti, H.,Mooney, C.J.,Patel, S.,Tang, C.M.,Ward, M.,Wonacott, A.J.,Wharton, C.W.; Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.; Biochemistry, 37:6645-6657, 1998; PubMed: 9578548; DOI: 10.1021/bi972499o

Experimental method

X-RAY DIFFRACTION (3 Å)