1AW4

STRUCTURAL BASIS OF DNA FOLDING AND RECOGNITION IN AMP-DNA APTAMER COMPLEX, NMR, 7 STRUCTURES

Summary for 1AW4

Entry DOI	10.2210/pdb1aw4/pdb
Descriptor	ATP-BINDING DNA APTAMER, ADENOSINE MONOPHOSPHATE (2 entities in total)
Functional Keywords	adaptive binding, amp binding, dna aptamer, dna binding, dna recognition, amp-dna aptamer complex, dna
Total number of polymer chains	1
Total formula weight	9196.91
Authors	Lin, C.H.,Patel, D.J. (deposition date: 1997-10-09, release date: 1998-04-15, Last modification date: 2024-05-22)
Primary citation	Lin, C.H.,Patel, D.J. Structural basis of DNA folding and recognition in an AMP-DNA aptamer complex: distinct architectures but common recognition motifs for DNA and RNA aptamers complexed to AMP. Chem.Biol., 4:817-832, 1997 Cited by PubMed Abstract: Structural studies by nuclear magnetic resonance (NMR) of RNA and DNA aptamer complexes identified through in vitro selection and amplification have provided a wealth of information on RNA and DNA tertiary structure and molecular recognition in solution. The RNA and DNA aptamers that target ATP (and AMP) with micromolar affinity exhibit distinct binding site sequences and secondary structures. We report below on the tertiary structure of the AMP-DNA aptamer complex in solution and compare it with the previously reported tertiary structure of the AMP-RNA aptamer complex in solution. PubMed: 9384529 DOI: 10.1016/S1074-5521(97)90115-0 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation