1AVC

BOVINE ANNEXIN VI (CALCIUM-BOUND)

1AVC の概要

• エントリーDOI: 10.2210/pdb1avc/pdb
• 分子名称: ANNEXIN VI, CALCIUM ION (3 entities in total)
• 機能のキーワード: annexin, calcium-binding, membrane-binding, calcium/phospholipid-binding protein, calcium-phospholipid-binding protein complex
• 由来する生物種: Bos taurus (cattle)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 76251.97

構造登録者

Avila-Sakar, A.J.,Creutz, C.E.,Kretsinger, R.H. (登録日: 1997-09-16, 公開日: 1998-01-28, 最終更新日: 2024-05-22)

主引用文献

Avila-Sakar, A.J.,Creutz, C.E.,Kretsinger, R.H.
Crystal structure of bovine annexin VI in a calcium-bound state.
Biochim.Biophys.Acta, 1387:103-116, 1998

PubMed Abstract: The crystal structure of a calcium-bound form of bovine annexin VI has been determined with X-ray diffraction data to 2.9 A by molecular replacement. Six Ca2+ ions were found, five in AB loops, one in a DE loop. Two loops (II-AB, which binds calcium, and V-AB, which does not) have conformations that differ significantly from those in calcium-free, human recombinant annexin VI. There are only small differences between the calci- and the apo-annexin VI in the rest of the molecule. Calcium by itself does not promote a major conformational change.

PubMed: 9748523
DOI: 10.1016/S0167-4838(98)00111-3

実験手法

X-RAY DIFFRACTION (2.9 Å)