1AUJ

BOVINE TRYPSIN COMPLEXED TO META-CYANO-BENZYLIC INHIBITOR

1AUJ の概要

• エントリーDOI: 10.2210/pdb1auj/pdb
• 分子名称: TRYPSIN, CALCIUM ION, 1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID, ... (4 entities in total)
• 機能のキーワード: hydrolase, serine proteinase
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Secreted, extracellular space: P00760
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23798.66

構造登録者

Alexander, R.,Smallwood, A.,Kettner, C. (登録日: 1997-08-28, 公開日: 1998-10-14, 最終更新日: 2011-07-13)

• 主引用文献: Lee, S.L.,Alexander, R.S.,Smallwood, A.,Trievel, R.,Mersinger, L.,Weber, P.C.,Kettner, C.; New inhibitors of thrombin and other trypsin-like proteases: hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain.; Biochemistry, 36:13180-13186, 1997; PubMed: 9341205; DOI: 10.1021/bi970912m

実験手法

X-RAY DIFFRACTION (2.1 Å)