1AU6
SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE
Summary for 1AU6
| Entry DOI | 10.2210/pdb1au6/pdb |
| Descriptor | DNA (5'-D(*CP*AP*TP*GP*CP*AP*TP*G)-3'), BIS(TRANS-PLATINUM ETHYLENEDIAMINE DIAMINE CHLORO)COMPLEX (2 entities in total) |
| Functional Keywords | bisplatinum compound (1, 1/t, t), dna, interstrand crosslink, dumbbell structure, deoxyribonucleic acid |
| Total number of polymer chains | 2 |
| Total formula weight | 5470.57 |
| Authors | Yang, D.,Van Boom, S.S.G.E.,Reedijk, J.,Van Boom, J.H.,Farrell, N.,Wang, A.H.-J. (deposition date: 1997-09-11, release date: 1998-02-25, Last modification date: 2024-05-22) |
| Primary citation | Yang, D.,van Boom, S.S.,Reedijk, J.,van Boom, J.H.,Farrell, N.,Wang, A.H. A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA. Nat.Struct.Biol., 2:577-586, 1995 Cited by PubMed Abstract: The bifunctional platinum compound, [(trans-PtCI(NH)3)2)2(H2N(CH2)4NH2)]2+, forms a stable adduct with the self-complementary DNA oligomer CATGCATG, with the two platinum atoms coordinated at the N7 positions of the two symmetrical G4 nucleotides. The NMR-derived structure shows that the DNA octamer forms a novel hairpin structure with the platinated G4 residue adopting a syn conformation and the guanine base in the minor groove. Two such hairpins stack end-over-end and are linked together by the butanediamine tether to form a dumbbell structure. Such unusual structural distortion is different from that of the anticancer drug cisplatin-DNA adduct and may provide clues to explain the distinct biological activities of the two compounds. PubMed: 7664126DOI: 10.1038/nsb0795-577 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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