1AQR

CU-METALLOTHIONEIN FROM SACCHAROMYCES CEREVISIAE, NMR, MINIMIZED AVERAGE STRUCTURE

Summary for 1AQR

Entry DOI	10.2210/pdb1aqr/pdb
Descriptor	CU-METALLOTHIONEIN, COPPER (I) ION (2 entities in total)
Functional Keywords	metallothionein, copper detoxification, metal-thiolate cluster
Biological source	Saccharomyces cerevisiae (baker's yeast)
Total number of polymer chains	1
Total formula weight	4720.48
Authors	Peterson, C.W.,Narula, S.S.,Armitage, I.M. (deposition date: 1997-07-31, release date: 1997-12-24, Last modification date: 2024-05-22)
Primary citation	Peterson, C.W.,Narula, S.S.,Armitage, I.M. 3D solution structure of copper and silver-substituted yeast metallothioneins. FEBS Lett., 379:85-93, 1996 Cited by PubMed Abstract: 3D solution structural calculations for yeast silver(I)-substituted metallothionein (MT) and native copper(I) MT were completed using experimentally determined NOE and dihedral angle constraints, in conjunction with experimentally derived metal-to-Cys connectivities for AgMT which were assumed identical for CuMT. For the first 40 residues in both structures, the polypeptide backbone wraps around the metal cluster in two large parallel loops separated by a deep cleft containing the metal cluster. Minor differences between the two structures include differences in hydrogen bonds and the orientation of the N-terminus with the overall protein volume conserved to within 6.5%. PubMed: 8566237 DOI: 10.1016/0014-5793(95)01492-6 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation