1AOW

ANNEXIN IV

1AOW の概要

• エントリーDOI: 10.2210/pdb1aow/pdb
• 分子名称: ANNEXIN IV (1 entity in total)
• 機能のキーワード: calcium/phospholipid-binding protein, 32.5kd calelectrin, endonexin i, lipocortin iv, chromobindin iv, protein ii, calcium-phospholipid-binding protein complex
• 由来する生物種: Bos taurus (cattle)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35005.65

構造登録者

Zanotti, G.,Malpeli, G.,Gliubich, F.,Folli, C.,Stoppini, M.,Olivi, L.,Savoia, A.,Berni, R. (登録日: 1997-07-11, 公開日: 1998-01-14, 最終更新日: 2024-05-22)

主引用文献

Zanotti, G.,Malpeli, G.,Gliubich, F.,Folli, C.,Stoppini, M.,Olivi, L.,Savoia, A.,Berni, R.
Structure of the trigonal crystal form of bovine annexin IV.
Biochem.J., 329:101-106, 1998

PubMed Abstract: The structure of a trigonal crystal form of N-terminally truncated [des-(1-9)] bovine annexin IV, an annexin variant that exhibits the distinctive property of binding both phospholipids and carbohydrates in a Ca2+-dependent manner, has been determined at 3 A (0.3 nm) resolution -space group: R3; cell parameters: a=b=118.560 (8) A and c=82.233 (6) A-. The overall structure of annexin IV, crystallized in the absence of Ca2+ ions, is highly homologous to that of the other known members of the annexin family. The trimeric assembly in the trigonal crystals of annexin IV is quite similar to that found previously in non-isomorphous crystals of human, chicken and rat annexin V and to the subunit arrangement in half of the hexamer of hydra annexin XII. Moreover, it resembles that found in two-dimensional crystals of human annexin V bound to phospholipid monolayers. The propensity of several annexins to generate similar trimeric arrays supports the hypothesis that trimeric complexes of such annexins, including annexin IV, may represent the functional units that interact with membranes.

PubMed: 9405281

実験手法

X-RAY DIFFRACTION (3 Å)