1AOJ

THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER

1AOJ の概要

• エントリーDOI: 10.2210/pdb1aoj/pdb
• 分子名称: EPS8 (2 entities in total)
• 機能のキーワード: signal transduction, sh3 domain, eps8, proline rich peptide
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 14089.92

構造登録者

Kishan, K.V.R.,Newcomer, M.E. (登録日: 1997-07-07, 公開日: 1998-07-08, 最終更新日: 2024-05-22)

主引用文献

Kishan, K.V.,Scita, G.,Wong, W.T.,Di Fiore, P.P.,Newcomer, M.E.
The SH3 domain of Eps8 exists as a novel intertwined dimer.
Nat.Struct.Biol., 4:739-743, 1997

PubMed Abstract: SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.

PubMed: 9303002
DOI: 10.1038/nsb0997-739

実験手法

X-RAY DIFFRACTION (2.5 Å)