1AMT

Crystal structure of alamethicin at 1.5 angstrom resolution

1AMT の概要

• エントリーDOI: 10.2210/pdb1amt/pdb
• 関連するPDBエントリー: 1DLZ 1EE7 1GQ0 1IH9 1JOH 1M24 1OB4 1OB6 1OB7 1R9U
• 関連するBIRD辞書のPRD_ID: PRD_000163
• 分子名称: ALAMETHICIN F30, ACETONITRILE, METHANOL (3 entities in total)
• 機能のキーワード: alamethicin, peptaibol, antibacterial, antifungal, antibiotic
• 由来する生物種: TRICHODERMA VIRIDE
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 6343.58

構造登録者

Fox, R.O.,Richards, F.M. (登録日: 1987-12-08, 公開日: 1988-10-09, 最終更新日: 2025-03-26)

主引用文献

Fox Jr, R.O.,Richards, F.M.
A Voltage-Gated Ion Channel Model Inferred from the Crystal Structure of Alamethicin at 1.5-A Resolution.
Nature, 300:325-, 1982

PubMed Abstract: The crystal structure of alamethicin in nonaqueous solvent has been determined, and refined at 1.5-A resolution. The molecular conformation of the three crystallographically independent molecules is largely alpha-helical with a bend in the helix axis at an internal proline residue. The helix structure is highly amphipathic as most of the solvent-accessible polar atoms lie on a narrow strip of surface parallel to the helix axis. Molecular models for the voltage-gated ion channel, with n-fold symmetry and based on the molecular conformations observed in the crystal, are characterized by strong surface complementarity, a hydrophilic interior and a hydrophobic exterior. The channel structures are stabilized by a hydrated annulus of hydrogen-bonded glutamine residues which produce the greatest restriction in the channel diameter.

PubMed: 6292726
DOI: 10.1038/300325A0

実験手法

X-RAY DIFFRACTION (1.5 Å)