1AGQ

GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT

Summary for 1AGQ

Entry DOI	10.2210/pdb1agq/pdb
Descriptor	GLIAL CELL-DERIVED NEUROTROPHIC FACTOR (2 entities in total)
Functional Keywords	growth factor, neurotrophic factor, cystine knot
Biological source	Rattus norvegicus (Norway rat)
Total number of polymer chains	4
Total formula weight	60361.02
Authors	Eigenbrot, C.,Gerber, N. (deposition date: 1997-03-25, release date: 1997-06-05, Last modification date: 2011-07-13)
Primary citation	Eigenbrot, C.,Gerber, N. X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding. Nat.Struct.Biol., 4:435-438, 1997 Cited by PubMed Abstract: The crystal structure of glial cell-derived neurotrophic factor (GDNF) reveals two independent copies of the dimer that differ significantly through a hinge bending at the central, disulphide-rich region. GDNF is compared with other members of the TGF-beta family, and potential receptor binding surfaces are identified. PubMed: 9187648 DOI: 10.1038/nsb0697-435 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation