1AD6

DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR

Summary for 1AD6

• Entry DOI: 10.2210/pdb1ad6/pdb
• Descriptor: RETINOBLASTOMA TUMOR SUPPRESSOR (2 entities in total)
• Functional Keywords: transcription regulation, tumor suppressor, dna-binding
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 21335.74

Authors

Kim, H.Y.,Cho, Y. (deposition date: 1997-02-21, release date: 1998-08-26, Last modification date: 2024-02-07)

Primary citation

Kim, H.Y.,Cho, Y.
Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box.
Nat.Struct.Biol., 4:390-395, 1997

PubMed Abstract: The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.

PubMed: 9145110
DOI: 10.1038/nsb0597-390

Experimental method

X-RAY DIFFRACTION (2.3 Å)