1AAX

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES

1AAX の概要

• エントリーDOI: 10.2210/pdb1aax/pdb
• 分子名称: PROTEIN TYROSINE PHOSPHATASE 1B, MAGNESIUM ION, 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN, ... (4 entities in total)
• 機能のキーワード: complex (hydrolase-inhibitor), hydrolase, phosphorylation, non-peptide inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38022.20

構造登録者

Puius, Y.A.,Zhao, Y.,Sullivan, M.,Lawrence, D.,Almo, S.C.,Zhang, Z.-Y. (登録日: 1997-01-16, 公開日: 1998-03-04, 最終更新日: 2024-05-22)

• 主引用文献: Puius, Y.A.,Zhao, Y.,Sullivan, M.,Lawrence, D.S.,Almo, S.C.,Zhang, Z.Y.; Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.; Proc.Natl.Acad.Sci.USA, 94:13420-13425, 1997; PubMed: 9391040; DOI: 10.1073/pnas.94.25.13420

実験手法

X-RAY DIFFRACTION (1.9 Å)