1AAQ

HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS

1AAQ の概要

• エントリーDOI: 10.2210/pdb1aaq/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000320
• 分子名称: HIV-1 PROTEASE, methyl N-{(4S,5S)-5-[(L-alanyl-L-alanyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-valyl-L-valinate (3 entities in total)
• 機能のキーワード: acid protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22185.22

構造登録者

Lewis, M. (登録日: 1992-04-13, 公開日: 1994-06-22, 最終更新日: 2024-02-07)

• 主引用文献: Dreyer, G.B.,Lambert, D.M.,Meek, T.D.,Carr, T.J.,Tomaszek Jr., T.A.,Fernandez, A.V.,Bartus, H.,Cacciavillani, E.,Hassell, A.M.,Minnich, M.,Petteway Jr., S.R.,Metcalf, B.W.; Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays.; Biochemistry, 31:6646-6659, 1992; PubMed: 1637805; DOI: 10.1021/bi00144a004

実験手法

X-RAY DIFFRACTION (2.5 Å)