1AAQ
HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS
1AAQ の概要
エントリーDOI | 10.2210/pdb1aaq/pdb |
関連するBIRD辞書のPRD_ID | PRD_000320 |
分子名称 | HIV-1 PROTEASE, methyl N-{(4S,5S)-5-[(L-alanyl-L-alanyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-valyl-L-valinate (3 entities in total) |
機能のキーワード | acid protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Human immunodeficiency virus 1 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 22185.22 |
構造登録者 | |
主引用文献 | Dreyer, G.B.,Lambert, D.M.,Meek, T.D.,Carr, T.J.,Tomaszek Jr., T.A.,Fernandez, A.V.,Bartus, H.,Cacciavillani, E.,Hassell, A.M.,Minnich, M.,Petteway Jr., S.R.,Metcalf, B.W. Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays. Biochemistry, 31:6646-6659, 1992 Cited by PubMed: 1637805DOI: 10.1021/bi00144a004 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.5 Å) |
構造検証レポート
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