1A81

CRYSTAL STRUCTURE OF THE TANDEM SH2 DOMAIN OF THE SYK KINASE BOUND TO A DUALLY TYROSINE-PHOSPHORYLATED ITAM

Summary for 1A81

Entry DOI	10.2210/pdb1a81/pdb
Descriptor	SYK KINASE, T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN (2 entities in total)
Functional Keywords	complex (transferase-peptide), syk, kinase, sh2 domain, itam, complex (transferase-peptide) complex, complex (transferase/peptide)
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane : P43405 Cell membrane ; Single-pass type I membrane protein : P07766
Total number of polymer chains	12
Total formula weight	186697.03
Authors	Fuetterer, K.,Waksman, G. (deposition date: 1998-03-31, release date: 1998-10-21, Last modification date: 2016-05-25)
Primary citation	Futterer, K.,Wong, J.,Grucza, R.A.,Chan, A.C.,Waksman, G. Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. J.Mol.Biol., 281:523-537, 1998 Cited by PubMed: 9698567 DOI: 10.1006/jmbi.1998.1964 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation