1A81

CRYSTAL STRUCTURE OF THE TANDEM SH2 DOMAIN OF THE SYK KINASE BOUND TO A DUALLY TYROSINE-PHOSPHORYLATED ITAM

1A81 の概要

• エントリーDOI: 10.2210/pdb1a81/pdb
• 分子名称: SYK KINASE, T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN (2 entities in total)
• 機能のキーワード: complex (transferase-peptide), syk, kinase, sh2 domain, itam, complex (transferase-peptide) complex, complex (transferase/peptide)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane : P43405; Cell membrane ; Single-pass type I membrane protein : P07766
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 186697.03

構造登録者

Fuetterer, K.,Waksman, G. (登録日: 1998-03-31, 公開日: 1998-10-21, 最終更新日: 2016-05-25)

• 主引用文献: Futterer, K.,Wong, J.,Grucza, R.A.,Chan, A.C.,Waksman, G.; Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.; J.Mol.Biol., 281:523-537, 1998; PubMed: 9698567; DOI: 10.1006/jmbi.1998.1964

実験手法

X-RAY DIFFRACTION (3 Å)