1A6A

THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3

1A6A の概要

• エントリーDOI: 10.2210/pdb1a6a/pdb
• 分子名称: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DR-1 beta chain, HLA class II histocompatibility antigen, gamma chain, ... (5 entities in total)
• 機能のキーワード: mhc glycoprotein, complex (transmembrane-glycoprotein), complex (transmembrane-glycoprotein) complex, complex (transmembrane/glycoprotein)
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44523.09

構造登録者

Ghosh, P.,Amaya, M.,Mellins, E.,Wiley, D.C. (登録日: 1998-02-22, 公開日: 1998-05-27, 最終更新日: 2024-10-23)

主引用文献

Ghosh, P.,Amaya, M.,Mellins, E.,Wiley, D.C.
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.
Nature, 378:457-462, 1995

PubMed Abstract: A complex between HLA-DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain-DR3 and antigenic peptide-DR3 complexes. The structure shows that the CLIP fragment binds to DR3 in a way almost identical to that in which antigenic peptides bind class II histocompatibility glycoproteins. The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM.

PubMed: 7477400
DOI: 10.1038/378457a0

実験手法

X-RAY DIFFRACTION (2.75 Å)