1A46

THROMBIN COMPLEXED WITH HIRUGEN AND A BETA-STRAND MIMETIC INHIBITOR

Summary for 1A46

Related PRD IDPRD_000617
DescriptorALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ... (6 entities in total)
Functional Keywordscomplex (serine protease-inhibitor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationSecreted, extracellular space P00734 P09945
Secreted P00734
Total number of polymer chains3
Total molecular weight35985.97
Authors
St Charles, R.,Matthews, J.H.,Zhang, E.,Tulinsky, A.,Kahn, M. (deposition date: 1998-02-11, release date: 1998-05-27, Last modification date: 2012-12-12)
Primary citation
St Charles, R.,Matthews, J.H.,Zhang, E.,Tulinsky, A.
Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.
J.Med.Chem., 42:1376-1383, 1999
PubMed: 10212123 (PDB entries with the same primary citation)
DOI: 10.1021/jm980052n
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.12 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers200.7%13.5%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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