1A35

HUMAN TOPOISOMERASE I/DNA COMPLEX

Summary for 1A35

• Entry DOI: 10.2210/pdb1a35/pdb
• Descriptor: DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*(BRU)P*(BRU)P*TP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*+UP*+UP*+UP*+UP*CP*+UP*AP*AP*GP*TP*CP*TP*TP*TP*+ UP*T)-3'), PROTEIN (DNA TOPOISOMERASE I), ... (4 entities in total)
• Functional Keywords: topoisomerase i/dna), dna, topoisomerase i, isomerase-dna complex, isomerase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleolus: P11387
• Total number of polymer chains: 3
• Total formula weight: 84037.66

Authors

Redinbo, M.R.,Stewart, L.,Kuhn, P.,Champoux, J.J.,Hol, W.G. (deposition date: 1998-01-29, release date: 1998-08-28, Last modification date: 2024-04-03)

• Primary citation: Redinbo, M.R.,Stewart, L.,Kuhn, P.,Champoux, J.J.,Hol, W.G.; Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.; Science, 279:1504-1513, 1998; PubMed: 9488644; DOI: 10.1126/science.279.5356.1504

Experimental method

X-RAY DIFFRACTION (2.5 Å)