1A2N

STRUCTURE OF THE C115A MUTANT OF MURA COMPLEXED WITH THE FLUORINATED ANALOG OF THE REACTION TETRAHEDRAL INTERMEDIATE

Summary for 1A2N

DescriptorUDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE, URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL-3-FLUORO-2-PHOSPHONOOXY)PROPIONIC ACID (3 entities in total)
Functional Keywordstransferase, peptidoglycan synthesis, enolpyruvyl transferase, udp-n-acetylglucosamine
Biological sourceEscherichia coli
Cellular locationCytoplasm (Probable) P0A749
Total number of polymer chains1
Total molecular weight45632.86
Authors
Skarzynski, T. (deposition date: 1998-01-06, release date: 1998-04-29, Last modification date: 2011-07-13)
Primary citation
Skarzynski, T.,Kim, D.H.,Lees, W.J.,Walsh, C.T.,Duncan, K.
Stereochemical course of enzymatic enolpyruvyl transfer and catalytic conformation of the active site revealed by the crystal structure of the fluorinated analogue of the reaction tetrahedral intermediate bound to the active site of the C115A mutant of MurA
Biochemistry, 37:2572-2577, 1998
PubMed: 9485407 (PDB entries with the same primary citation)
DOI: 10.1021/bi9722608
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers131.0%7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1a2n.pdb1.gz [207.82 KB])