1A1R

HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX

1A1R の概要

• エントリーDOI: 10.2210/pdb1a1r/pdb
• 分子名称: NS3 PROTEIN, NS4A PROTEIN, ZINC ION, ... (4 entities in total)
• 機能のキーワード: viral protein, serine protease, nonstructural proteins, cofactor peptide, helicase
• 由来する生物種: Hepatitis C virus; 詳細
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P27958 P27958
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 47008.85

構造登録者

Kim, J.L.,Morgenstern, K.A.,Lin, C.,Fox, T.,Dwyer, M.D.,Landro, J.A.,Chambers, S.P.,Markland, W.,Lepre, C.A.,O'Malley, E.T.,Harbeson, S.L.,Rice, C.M.,Murcko, M.A.,Caron, P.R.,Thomson, J.A. (登録日: 1997-12-15, 公開日: 1998-06-17, 最終更新日: 2024-02-07)

• 主引用文献: Kim, J.L.,Morgenstern, K.A.,Lin, C.,Fox, T.,Dwyer, M.D.,Landro, J.A.,Chambers, S.P.,Markland, W.,Lepre, C.A.,O'Malley, E.T.,Harbeson, S.L.,Rice, C.M.,Murcko, M.A.,Caron, P.R.,Thomson, J.A.; Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide.; Cell(Cambridge,Mass.), 87:343-355, 1996; PubMed: 8861917; DOI: 10.1016/S0092-8674(00)81351-3

実験手法

X-RAY DIFFRACTION (2.5 Å)