1A0H

THE X-RAY CRYSTAL STRUCTURE OF PPACK-MEIZOTHROMBIN DESF1: KRINGLE/THROMBIN AND CARBOHYDRATE/KRINGLE/THROMBIN INTERACTIONS AND LOCATION OF THE LINKER CHAIN

Summary for 1A0H

Entry DOI	10.2210/pdb1a0h/pdb
Related PRD ID	PRD_000020
Descriptor	MEIZOTHROMBIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (5 entities in total)
Functional Keywords	serine protease, coagulation, thrombin, prothrombin, meizothrombin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Bos taurus (cattle) More
Total number of polymer chains	4
Total formula weight	97038.29
Authors	Martin, P.D.,Malkowski, M.G.,Box, J.,Esmon, C.T.,Edwards, B.F.P. (deposition date: 1997-11-30, release date: 1998-06-17, Last modification date: 2024-04-03)
Primary citation	Martin, P.D.,Malkowski, M.G.,Box, J.,Esmon, C.T.,Edwards, B.F. New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK. Structure, 5:1681-1693, 1997 Cited by PubMed: 9438869 DOI: 10.1016/S0969-2126(97)00314-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation