1ZOM
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with a peptidomimetic Inhibitor
Summary for 1ZOM
Entry DOI | 10.2210/pdb1zom/pdb |
Descriptor | Coagulation factor XI, SULFATE ION, (S)-2-(3-((R)-1-(4-BROMOPHENYL)ETHYL)UREIDO)-N-((S)-1-((S)-5-GUANIDINO-1-OXO-1-(THIAZOL-2-YL)PENTAN-2-YLAMINO)-3-METHYL-1-OXOBUTAN-2-YL)-5-UREIDOPENTANAMIDE, ... (4 entities in total) |
Functional Keywords | fxia, inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P03951 |
Total number of polymer chains | 1 |
Total formula weight | 27574.13 |
Authors | Lin, J.,Deng, H.,Jin, L.,Pandey, P.,Rynkiewicz, M.,Bibbins, F.,Cantin, S.,Quinn, J.,Magee, S.,Gorga, J. (deposition date: 2005-05-13, release date: 2006-05-23, Last modification date: 2023-08-23) |
Primary citation | Lin, J.,Deng, H.,Jin, L.,Pandey, P.,Quinn, J.,Cantin, S.,Rynkiewicz, M.J.,Gorga, J.C.,Bibbins, F.,Celatka, C.A.,Nagafuji, P.,Bannister, T.D.,Meyers, H.V.,Babine, R.E.,Hayward, N.J.,Weaver, D.,Benjamin, H.,Stassen, F.,Abdel-Meguid, S.S.,Strickler, J.E. Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants. J.Med.Chem., 49:7781-7791, 2006 Cited by PubMed: 17181160DOI: 10.1021/jm060978s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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