1ZGV

Thrombin in complex with an oxazolopyridine inhibitor 2

Summary for 1ZGV

Entry DOI	10.2210/pdb1zgv/pdb
Related	1ZGI
Descriptor	Thrombin, Hirudin, N7-BUTYL-N2-(5-CHLORO-2-METHYLPHENYL)-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-2,7-DIAMINE, ... (4 entities in total)
Functional Keywords	thrombin, thrombin inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 Secreted: P28511
Total number of polymer chains	2
Total formula weight	34788.21
Authors	Deng, J.Z.,McMasters, D.R.,Rabbat, P.M.,Williams, P.D.,Coburn, C.A.,Yan, Y.,Kuo, L.C.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Strulovici, B.,Vacca, J.P.,Lyle, T.A.,Burgey, C.S. (deposition date: 2005-04-22, release date: 2005-09-27, Last modification date: 2013-03-13)
Primary citation	Deng, J.Z.,McMasters, D.R.,Rabbat, P.M.,Williams, P.D.,Coburn, C.A.,Yan, Y.,Kuo, L.C.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Strulovici, B.,Vacca, J.P.,Lyle, T.A.,Burgey, C.S. Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization. Bioorg.Med.Chem.Lett., 15:4411-4416, 2005 Cited by PubMed: 16137886 DOI: 10.1016/j.bmcl.2005.07.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation