1ZE8
Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor
Summary for 1ZE8
Entry DOI | 10.2210/pdb1ze8/pdb |
Descriptor | Carbonic anhydrase II, ZINC ION, 4-(HYDROXYMERCURY)BENZOIC ACID, ... (6 entities in total) |
Functional Keywords | twisted beta-sheet, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29959.49 |
Authors | Menchise, V.,De Simone, G.,Alterio, V.,Di Fiore, A.,Pedone, C.,Scozzafava, A.,Supuran, C.T. (deposition date: 2005-04-18, release date: 2005-10-18, Last modification date: 2024-03-13) |
Primary citation | Menchise, V.,De Simone, G.,Alterio, V.,Di Fiore, A.,Pedone, C.,Scozzafava, A.,Supuran, C.T. Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II J.Med.Chem., 48:5721-5727, 2005 Cited by PubMed: 16134940DOI: 10.1021/jm050333c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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