1Z71

thrombin and P2 pyridine N-oxide inhibitor complex structure

Summary for 1Z71

• Entry DOI: 10.2210/pdb1z71/pdb
• Descriptor: thrombin, Hirudin IIIB', L17, ... (4 entities in total)
• Functional Keywords: thrombin inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734; Secreted: P28511
• Total number of polymer chains: 2
• Total formula weight: 35011.76

Authors

Nantermet, P.G.,Burgey, C.S.,Robinson, K.A.,Pellicore, J.M.,Newton, C.L.,Deng, J.Z.,Lyle, T.A.,Selnick, H.G.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Miller-Stein, C.,White, R.B.,Wong, B.,McMasters, D.R.,Wallace, A.A.,Lynch Jr., J.J.,Yan, Y.,Chen, Z.,Kuo, L.,Gardell, S.J.,Shafer, J.A.,Vacca, J.P. (deposition date: 2005-03-23, release date: 2005-05-17, Last modification date: 2017-10-11)

• Primary citation: Nantermet, P.G.,Burgey, C.S.,Robinson, K.A.,Pellicore, J.M.,Newton, C.L.,Deng, J.Z.,Selnick, H.G.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Miller-Stein, C.,White, R.B.,Wong, B.,McMasters, D.R.,Wallace, A.A.,Lynch Jr., J.J.,Yan, Y.,Chen, Z.,Kuo, L.,Gardell, S.J.,Shafer, J.A.,Vacca, J.P.,Lyle, T.A.; P(2) pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold; BIOORG.MED.CHEM.LETT., 15:2771-2775, 2005; PubMed: 15911253; DOI: 10.1016/j.bmcl.2005.03.110

Experimental method

X-RAY DIFFRACTION (1.8 Å)