1Y9R
Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to deoxycorticosterone and harboring the S810L mutation responsible for a severe form of hypertension
Summary for 1Y9R
Entry DOI | 10.2210/pdb1y9r/pdb |
Descriptor | Mineralocorticoid receptor, DESOXYCORTICOSTERONE (3 entities in total) |
Functional Keywords | mineralocorticoid receptor; steroid receptor; nuclear recept; transcription regulation; activating mutation; hypertension, transcription, ligand binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P08235 |
Total number of polymer chains | 2 |
Total formula weight | 59949.64 |
Authors | Fagart, J.,Huyet, J.,Pinon, G.M.,Rochel, M.,Mayer, C.,Rafestin-Oblin, M.E. (deposition date: 2004-12-16, release date: 2005-05-24, Last modification date: 2024-04-03) |
Primary citation | Fagart, J.,Huyet, J.,Pinon, G.M.,Rochel, M.,Mayer, C.,Rafestin-Oblin, M.E. Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension Nat.Struct.Mol.Biol., 12:554-555, 2005 Cited by PubMed: 15908963DOI: 10.1038/nsmb939 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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