1Y9R

Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to deoxycorticosterone and harboring the S810L mutation responsible for a severe form of hypertension

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Mineralocorticoid receptor	polymer	255	29644.4	2	UniProt (P08235) Pfam (PF00104)	Homo sapiens (human)	MR; nuclear receptor subfamily 3, group C, member 2
2	C, D (A, B)	DESOXYCORTICOSTERONE	non-polymer		330.5	2	Chemie (1CA)
3	E, F (A, B)	water	water		18.0	461	Chemie (HOH)

Sequence modifications

A, B: 731 - 984 (UniProt: P08235)

PDB	External Database	Details
Ser 730	-	cloning artifact
Leu 810	Ser 810	engineered mutation
Ala 910	Cys 910	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	59288.7
Non-Polymers*	Number of molecules	2
	Total formula weight	660.9
All*	Total formula weight	59949.6

*Water molecules are not included.