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1XAK

STRUCTURE OF THE SARS-CORONAVIRUS ORF7A ACCESSORY PROTEIN

Summary for 1XAK
Entry DOI10.2210/pdb1xak/pdb
DescriptorSARS ORF7A ACCESSORY PROTEIN (2 entities in total)
Functional Keywordsi-set ig domain, beta sandwich, structural genomics, psi, protein structure initiative, midwest center for structural genomics, mcsg, viral protein
Biological sourceSARS coronavirus
Cellular locationVirion: P59635
Total number of polymer chains1
Total formula weight9424.54
Authors
Nelson, C.A.,Lee, C.A.,Fremont, D.H.,Midwest Center for Structural Genomics (MCSG) (deposition date: 2004-08-26, release date: 2004-10-05, Last modification date: 2024-10-30)
Primary citationNelson, C.A.,Pekosz, A.,Lee, C.A.,Diamond, M.S.,Fremont, D.H.
Structure and intracellular targeting of the SARS-coronavirus Orf7a accessory protein.
Structure, 13:75-85, 2005
Cited by
PubMed Abstract: The open reading frame (ORF) 7a of the SARS-associated coronavirus (SARS-CoV) encodes a unique type I transmembrane protein of unknown function. We have determined the 1.8 A resolution crystal structure of the N-terminal ectodomain of orf7a, revealing a compact seven-stranded beta sandwich unexpectedly similar in fold and topology to members of the Ig superfamily. We also demonstrate that, in SARS-CoV- infected cells, the orf7a protein is expressed and retained intracellularly. Confocal microscopy studies using orf7a and orf7a/CD4 chimeras implicate the short cytoplasmic tail and transmembrane domain in trafficking of the protein within the endoplasmic reticulum and Golgi network. Taken together, our findings provide a structural and cellular framework in which to explore the role of orf7a in SARS-CoV pathogenesis.
PubMed: 15642263
DOI: 10.1016/j.str.2004.10.010
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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