1WSS

Human Factor Viia-Tissue Factor in Complex with peptide-mimetic inhibitor that has two charged groups in P2 and P4

Summary for 1WSS

• Entry DOI: 10.2210/pdb1wss/pdb
• Related: 1DAN 1WQV
• Descriptor: Coagulation factor VII, Tissue factor, beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: serine protease, hydrolase-blood clotting complex, hydrolase/blood clotting
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 71580.44

Authors

Kadono, S.,Sakamoto, A.,Kikuchi, Y.,Oh-Eda, M.,Yabuta, N.,Koga, T.,Hattori, K.,Shiraishi, T.,Haramura, M.,Kodama, H.,Ono, Y.,Esaki, T.,Sato, H.,Watanabe, Y.,Itoh, S.,Ohta, M.,Kozono, T. (deposition date: 2004-11-10, release date: 2005-11-10, Last modification date: 2023-11-15)

• Primary citation: Kadono, S.,Sakamoto, A.,Kikuchi, Y.,Oh-Eda, M.,Yabuta, N.,Koga, T.,Hattori, K.,Shiraishi, T.,Haramura, M.,Kodama, H.,Ono, Y.,Esaki, T.,Sato, H.,Watanabe, Y.,Itoh, S.,Ohta, M.,Kozono, T.; Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: high selectivity against thrombin by introducing two charged groups in P2 and P4.; Acta Crystallogr.,Sect.F, 61:169-173, 2005; PubMed: 16510984; DOI: 10.1107/S1744309105000047

Experimental method

X-RAY DIFFRACTION (2.6 Å)