1WSS
Human Factor Viia-Tissue Factor in Complex with peptide-mimetic inhibitor that has two charged groups in P2 and P4
Summary for 1WSS
Entry DOI | 10.2210/pdb1wss/pdb |
Related | 1DAN 1WQV |
Descriptor | Coagulation factor VII, Tissue factor, beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | serine protease, hydrolase-blood clotting complex, hydrolase/blood clotting |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 71580.44 |
Authors | Kadono, S.,Sakamoto, A.,Kikuchi, Y.,Oh-Eda, M.,Yabuta, N.,Koga, T.,Hattori, K.,Shiraishi, T.,Haramura, M.,Kodama, H.,Ono, Y.,Esaki, T.,Sato, H.,Watanabe, Y.,Itoh, S.,Ohta, M.,Kozono, T. (deposition date: 2004-11-10, release date: 2005-11-10, Last modification date: 2023-11-15) |
Primary citation | Kadono, S.,Sakamoto, A.,Kikuchi, Y.,Oh-Eda, M.,Yabuta, N.,Koga, T.,Hattori, K.,Shiraishi, T.,Haramura, M.,Kodama, H.,Ono, Y.,Esaki, T.,Sato, H.,Watanabe, Y.,Itoh, S.,Ohta, M.,Kozono, T. Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: high selectivity against thrombin by introducing two charged groups in P2 and P4. Acta Crystallogr.,Sect.F, 61:169-173, 2005 Cited by PubMed: 16510984DOI: 10.1107/S1744309105000047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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