1W6K
Structure of human OSC in complex with Lanosterol
Summary for 1W6K
Entry DOI | 10.2210/pdb1w6k/pdb |
Related | 1W6J |
Descriptor | LANOSTEROL SYNTHASE, octyl beta-D-glucopyranoside, LANOSTEROL, ... (4 entities in total) |
Functional Keywords | cyclase, cholesterol, lanosterol, monotopic membrane protein, b-octyl-glucoside, isomerase, steroid biosynthesis |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P48449 |
Total number of polymer chains | 1 |
Total formula weight | 86158.29 |
Authors | Thoma, R.,Schulz-Gasch, T.,D'Arcy, B.,Benz, J.,Aebi, J.,Dehmlow, H.,Hennig, M.,Ruf, A. (deposition date: 2004-08-19, release date: 2004-10-29, Last modification date: 2024-05-08) |
Primary citation | Thoma, R.,Schulz-Gasch, T.,D'Arcy, B.,Benz, J.,Aebi, J.,Dehmlow, H.,Hennig, M.,Stihle, M.,Ruf, A. Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase Nature, 432:118-, 2004 Cited by PubMed: 15525992DOI: 10.1038/NATURE02993 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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