1USN

CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THIADIAZOLE INHIBITOR PNU-142372

Summary for 1USN

Entry DOI	10.2210/pdb1usn/pdb
Descriptor	STROMELYSIN-1, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase, metalloprotease, fibroblast, collagen degradation
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P08254
Total number of polymer chains	1
Total formula weight	19339.52
Authors	Finzel, B.C.,Bryant Junior, G.L.,Baldwin, E.T. (deposition date: 1998-06-09, release date: 1998-12-23, Last modification date: 2023-08-09)
Primary citation	Finzel, B.C.,Baldwin, E.T.,Bryant Jr., G.L.,Hess, G.F.,Wilks, J.W.,Trepod, C.M.,Mott, J.E.,Marshall, V.P.,Petzold, G.L.,Poorman, R.A.,O'Sullivan, T.J.,Schostarez, H.J.,Mitchell, M.A. Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity. Protein Sci., 7:2118-2126, 1998 Cited by PubMed: 9792098 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation