Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 257 |
Chain | Residue |
A | HIS201 |
A | HIS205 |
A | HIS211 |
A | IN9300 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 258 |
Chain | Residue |
A | HIS151 |
A | ASP153 |
A | HIS166 |
A | HIS179 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 259 |
Chain | Residue |
A | ASP158 |
A | GLY159 |
A | GLY161 |
A | VAL163 |
A | ASP181 |
A | GLU184 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 260 |
Chain | Residue |
A | ASP141 |
A | GLY173 |
A | ASN175 |
A | ASP177 |
A | HOH307 |
A | HOH316 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA A 261 |
Chain | Residue |
A | ASP107 |
A | ASP182 |
A | GLU184 |
A | HOH321 |
A | HOH331 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ZN A 262 |
Chain | Residue |
A | HIS96 |
A | HIS96 |
A | HIS96 |
A | HOH263 |
A | HOH263 |
A | HOH263 |
site_id | AC7 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE IN9 A 300 |
Chain | Residue |
A | TYR155 |
A | HIS166 |
A | ALA167 |
A | TYR168 |
A | ALA169 |
A | THR190 |
A | THR191 |
A | GLU202 |
A | HIS205 |
A | HIS211 |
A | ZN257 |
A | HOH320 |
A | HOH380 |
site_id | CA1 |
Number of Residues | 6 |
Details | CA1 ARE THE LIGANDS OF THE CALCIUM ION CA 259. |
Chain | Residue |
A | ASP158 |
A | GLY159 |
A | GLY161 |
A | VAL163 |
A | ASP181 |
A | GLU184 |
site_id | CA2 |
Number of Residues | 6 |
Details | CA2 ARE THE LIGANDS OF THE CALCIUM ION CA 260. |
Chain | Residue |
A | ASP141 |
A | GLY173 |
A | ASN175 |
A | ASP177 |
A | HOH306 |
A | HOH312 |
site_id | CA3 |
Number of Residues | 3 |
Details | CA3 ARE THE LIGANDS OF THE CALCIUM ION CA 261. |
Chain | Residue |
A | ASP107 |
A | ASP182 |
A | GLU184 |
site_id | INH |
Number of Residues | 8 |
Details | SITE INH IS THE BINDING SITE FOR THE UREA-THIADIAZOLE INHIBITOR PNU-142372; IN9 300. |
Chain | Residue |
A | PHE86 |
A | TYR155 |
A | HIS166 |
A | ALA167 |
A | TYR168 |
A | ALA169 |
A | HIS205 |
A | PHE210 |
site_id | ZN1 |
Number of Residues | 4 |
Details | ZN1 ARE THE LIGANDS OF THE CATALYTIC (ZN 257) ZINC ION. |
Chain | Residue |
A | HIS205 |
A | HIS211 |
A | IN9300 |
A | HIS201 |
site_id | ZN2 |
Number of Residues | 4 |
Details | ZN2 ARE THE LIGANDS OF THE STRUCTURAL (ZN 258) ZINC ION. |
Chain | Residue |
A | HIS151 |
A | ASP153 |
A | HIS166 |
A | HIS179 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEIGHSL |
Chain | Residue | Details |
A | VAL198-LEU207 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | GLU202 | |
site_id | SWS_FT_FI2 |
Number of Residues | 16 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP107 | |
A | GLY173 | |
A | ASN175 | |
A | ASP177 | |
A | HIS179 | |
A | ASP181 | |
A | ASP182 | |
A | GLU184 | |
A | ASP141 | |
A | HIS151 | |
A | ASP153 | |
A | ASP158 | |
A | GLY159 | |
A | GLY161 | |
A | VAL163 | |
A | HIS166 | |
Chain | Residue | Details |
A | HIS201 | |
A | HIS205 | |
A | HIS211 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | MET219 | |
A | GLU202 | |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | GLU202 | |
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 591 |
Chain | Residue | Details |
A | HIS201 | metal ligand |
A | GLU202 | proton acceptor, proton donor |
A | HIS205 | metal ligand |
A | HIS211 | metal ligand |