1TNF

THE STRUCTURE OF TUMOR NECROSIS FACTOR-ALPHA AT 2.6 ANGSTROMS RESOLUTION. IMPLICATIONS FOR RECEPTOR BINDING

Summary for 1TNF

Entry DOI	10.2210/pdb1tnf/pdb
Descriptor	TUMOR NECROSIS FACTOR-ALPHA (1 entity in total)
Functional Keywords	lymphokine
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted: P01375
Total number of polymer chains	3
Total formula weight	52106.19
Authors	Eck, M.J.,Sprang, S.R. (deposition date: 1989-08-25, release date: 1990-01-15, Last modification date: 2011-07-13)
Primary citation	Eck, M.J.,Sprang, S.R. The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding. J.Biol.Chem., 264:17595-17605, 1989 Cited by PubMed: 2551905 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation